Cardano Set to Launch Bitcoin DeFi Integration on May 27, Targeting DeFi Growth

Crypto analyst Dan Gambardello has alerted Cardano holders to prepare for a major development and announced that the blockchain will roll out Bitcoin DeFi enablement on May 27. Gambardello advised ADA holders to lock in their positions ahead of what could be a major moment for the Cardano ecosystem.

The announcement comes as Cardano founder Charles Hoskinson has been actively promoting the blockchain’s role in Bitcoin decentralized finance. According to Gambardello’s alert, the May 27 launch could mark Cardano’s official entry into the growing Bitcoin DeFi sector. This could open new use cases and revenue streams for the ADA token.

Cardano rolling out Bitcoin DeFi enablement on May 27$ADA holders should lock in

— Dan Gambardello (@cryptorecruitr) May 20, 2025

Hoskinson Outlines Bitcoin DeFi Strategy

In recent public statements, Hoskinson has shared Cardano’s aggressive approach to capturing the Bitcoin DeFi market share. He explained that Bitcoin’s Taproot upgrade enables smart contract functionality, creating new opportunities for yield generation that were previously unavailable.

Hoskinson noted that Bitcoin now has the ability to pay yield because users can activate Bitcoin DeFi features and earn returns on their holdings. With nation-states, ETFs, and retail investors accumulating Bitcoin, the structural liquidity creates an enormous market opportunity.

The Cardano founder emphasized that his blockchain is competing to become the primary DeFi mode for Bitcoin. However, he acknowledged competition from projects like Stacks and dozens of other initiatives targeting the same opportunity.

Cardano will be in perfect position for enormous transaction volume from Bitcoin and $XRP DeFi. pic.twitter.com/rylDr97h5h

— TapTools (@TapTools) May 2, 2025

Hoskinson highlighted the scale of the Bitcoin DeFi opportunity. He pointed out that there’s already $5.8 billion in total value locked (TVL) from the Bitcoin side, and participants aren’t even actively trying to maximize this potential.

Bitcoin’s DeFi Potential

According to his analysis, if 5-10% of Bitcoin’s supply becomes involved in DeFi activities, the resulting TVL would exceed the entire market capitalization of Solana or potentially even Ethereum. He described Bitcoin as four times the size of Ethereum and Solana in terms of market opportunity.

This calculation suggests that successful Bitcoin DeFi integration could deliver huge returns for blockchains that capture meaningful market share in this emerging sector. Hoskinson has also detailed the technical foundations supporting Cardano’s Bitcoin DeFi ambitions. In his podcast, he described teams working on non-conflicting, independent components that will position Cardano for the major transaction volume that Bitcoin DeFi and other applications will generate.

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